Copper‐Catalyzed Oxidative Alkylation of Vinylic Cβ‐H of Enamides with Cyclic Ethers

Abstract

AbstractA general strategy for the oxidative alkylation of vinylic Cβ‐H bond of enamides catalyzed by copper to prepare structurally diverse ethers was developed. Under standard reaction conditions, various cyclic and acyclic enamides reacted well with cyclic ethers to afford the corresponding multi‐substituted alkene products in good yields. In addition, the coupling products could be converted into useful amino alcohol derivatives. The coupling reaction was considered to follow a mechanism based on radical pathway.