Abstract
Copper(II) chloride and novel bis(1-amino(cyclo)alkane-1-carboxylato-κ2N,O)copper(II) complexes as catalysts were studied in relation with enzymatic oxidation of amino acids. The oxidation of aminophosphonate derivative: (1-amino-1-methyl)ethylphosphonic acid was also investigated. Two bis(1-aminocycloalkane-1-carboxylato-κ2N,O)copper(II) complexes were structurally characterized. Surprisingly, while the 1-aminocyclobutane-1-carboxylate complex has square planar (SP-4) copper(II) center with trans-orientated ligands, the 1-aminocyclohexane-1-carboxylate complex has μ-carboxylato dimeric structure with square pyramidal (SPY-5) sites, one with cis- and one with trans-orientated ligands. Redox behavior of the bis(1-amino(cyclo)alkane-1-carboxylato-κ2N,O)copper(II) complexes was also investigated. Catalytic oxidations were carried out in alkaline DMF-water mixtures using H2O2 as oxidant and the complexes as catalysts. The observed potentials for the irreversible current peaks associated with the Cu(II) to Cu(I) reduction and the rates of the amino acid oxidations show inverse trend. This suggests that the Cu(II)/Cu(I) redox cycling due to the presence of H2O2 plays important role in the peroxide/copper activation that in turn provides the observed products.
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