Abstract
AbstractA versatile copper catalyzed one‐pot synthesis of diversely substituted pyrimidines directly from amides, N,N′‐dimethylformamide dimethylacetal (DMF−DMA) and enamines has been established. The reaction involved the two C−N bonds and one C−C bond formation by formal [2+1+3] annulation approach to pyrimidines. This protocol is based on the use of readily available primary amides, DMF−DMA and enamines to install di‐ and tri‐substituted pyrimidine structure with diverse functionality in one‐pot manner, which makes this strategy to be appealing for the medicinal chemistry.magnified image
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