Abstract

AbstractA general and mild strategy has been developed for the selective N‐arylation of tautomerizable heterocycles with a series of arylboronic acids, using CuOTf as the catalyst and 1,10‐Phen as the ligand, under base free conditions at ambient atmosphere. The reaction mechanism explored by using density functional methods revealed that both kinetic and thermodynamic controls favour N‐arylation. This “open‐flask” chemistry successfully applied for N‐arylation of benzo[d] oxazol‐2(3H)‐one and the designed N‐arylated product was subsequently manipulated in synthesizing various naturally occurring oxygenated carbazole alkaloids (e. g. clausenine, clauraila A, clausenal).

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.