Abstract
AbstractHerein, we report an efficient copper‐catalyzed aerobic Chan‐Lam type N‐arylation of various indoles and anilines with structurally diverse aryltrialkoxysilanes under mild conditions. This silicon‐based protocol enables the efficient C−N cross‐coupling of indoles and anilines with user‐friendly organosilicon reagents by employing inexpensive and nontoxic Cu(OAc)2, which is efficient and practical without the addition of other ligands, bases, and metal oxidants. This transformation is compatible with a wide range of substrates, and typically proceeds with high efficiency as well as with good functional group compatibility. A plausible mechanism involving the formation of Cu(III) species in the reaction was tentatively proposed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
