Abstract
Chiral borates can undergo various transformations that occur with high stereospecificity, so they are of great significance in asymmetric synthesis. Herein we described a new catalytic system for copper-catalyzed asymmetric conjugate hydroboration of α,β-unsaturated amides. Under the optimal conditions, the reactions proceeded smoothly to afford the corresponding chiral β-hydroxyl amides with up to 96% yield and 84% ee by employing chiral N,P-ligand. The reaction conditions are mild, the operation is simple, and it has good substrate generality.
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