Copper-catalyzed cross-coupling of 1-haloalkyl-o-carboranes with Grignard reagents: an efficient route to monosubstituted o-carborane derivatives

Abstract

A convenient and efficient copper-catalyzed reaction has been developed for the synthesis of functionalized o-carborane derivatives by using a Cu/phosphine catalytic system. Cross-coupling of readily available 1-haloalkyl-o-carboranes with Grignard reagents proceeds efficiently under mild conditions, and the corresponding monosubstituted o-carboranes were obtained in good to excellent yields.