Abstract
This paper especially deals with the problem associated with the reaction of α-bromocarboxyl compound and 5- membered ω-lactam ring. Specific heterogeneous copper catalyst was used to achieve the C – N nucleophilic coupling. Synthetic pathway of ethyl-6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxopyrrolidin-1-yl)hexanoate as the key intermediate of new potential transdermal enhancers is described. All generated compounds were characterized by NMR and IR spectroscopy. Keywords: Copper catalyst, C, –, N coupling, ω-lactam derivatives, penetration enhancers
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