Abstract
AbstractA copper‐catalyzed aerobic oxidative azo‐ene cyclization has been developed. The developed CuI/DMAP/O2 system efficiently facilitates the aerobic oxidation of ene‐containing hydrazides to azo compounds, which undergo azo‐ene cyclizations for the synthesis of oxazolidinones. In addition, the present approach enables the synthesis of lactams, as well as a nitroso‐ene cyclization. Preliminary mechanistic studies revealed that two carbonyl groups were essential for the successful azo‐ene cyclization and that a concerted mechanism might be plausible for this azo‐ene cyclization.magnified image
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