Abstract
That copper is an essential biocatalyst has been recognized for nearly a half century but its critical role in connective tissue metabolism has come into focus only in recent years. It is now clear that copper plays a role in the crosslinking of the two important connective tissue proteins, elastin and collagen. The gross pathology that results from this copper deficiency is most dramatic when it occurs in large arteries and results in spontaneous and massive hemorrhage. Because of this unique pathology and the importance of a sound vasculature to human health, our research has been focused on the aorta. The effect of copper deficiency on the integrity of collagen and elastin and the activity of the amine oxidases in this organ has been investigated. This paper summarizes earlier observations and presents recent results relating to a copper-dependent amine oxidase which plays a key role in the crosslinking process.
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