Abstract

Abstract Random copolypeptides have been considered as model compounds to understand, for instance, the conformational preference of individual monomers and the effect of comonomers on the folding of polypeptide chains [1,2]. The kinetics of copolymerization of N-carboxyanhydrides (NCA) of a-amino acids were reviewed earlier [3]. Reactivity ratios have been used in a few cases to determine the sequence length distribution and interchain heterogeneity [4] to arrive at the most probable primary structure for the polypeptide backbone. In the present communication we report the kinetics of copolymerization of e-benzyloxycarbonyl-Llysine NCA and Lvaline NCA in two solvents, dioxane and benzene/methylene chloride.

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