Abstract
The size distribution and composition of statistical copolymers has been investigated by size-exclusion chromatography (SEC) and off-line gradient high-performance liquid chromatography of the SEC fractions. The copolymers were poly(styrene—acrylonitrile) (SAN) and poly(styrene—methyl methacrylate) (SMMA) model mixtures. SAN copolymers were separated with a suitable gradient of increasing dissolution power on normal-phase columns as well as on reversed-phase columns. In contrast, SMMA copolymers were eluted from a reversed-phase column by a solubility gradient as broad bands, whereas the same gradient gave excellent resolution on a normal-phase column. The elution characteristics of SMMA samples roughly parallelled their solubility characteristics in the system investigated but there was an extra contribution to retention on active columns.
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