Copeptin in the Diagnosis and Differential Diagnosis of Diabetes Insipidus – The ‘CoSIP-Study’

Abstract

The correct differential diagnosis of the disorders related to polyuria-polydipsia syndrome (PPS) is mandatory since inadequate treatment may lead to serious complications. The diagnostic gold standard is the water deprivation test (WDT) with direct or indirect measurement of plasma vasopressin (AVP). But test interpretation is problematic, and direct measurement of AVP is hampered by methodological difficulties. The aim of this study was to evaluate the diagnostic accuracy of copeptin in the differential diagnosis of DI.