Copeptin and Obestatin Levels in Polycystic Ovary women and their Relation to Obesity, insulin metabolism and Cardiovascular diseases

Abstract

Objective: is to investigate the correlations between the serum levels of copeptin and obestatin, carotid artery intima-media thickness (CIMT), and brachial artery flow mediated dilatation (FMD) in obese and non-obese women with PCOS. Design: Prospective randomized study. Setting: Obstetrics and Gynecology Department, El-Hussein and Sayed Galal University Hospitals, Al-Azhar University. Patient(s): We analyzed 54 patients with PCOS and 20 normal women as controls. PCOS patients were divided into two groups based on body mass index (BMI): obese group (BMI > 30 kg/m2, n = 28) and non-obese group (BMI < 30 kg/m2, n = 26). Serum Copeptin and Obestatin levels, Insulin Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), CIMT and brachial artery FMD were determined and compared among both groups. Result(s): Serum Obestatin levels were significantly lower in obese PCOS group than non-obese and control. While Serum Copeptin levels were significantly higher in obese PCOS group than non-obese and control. Brachial artery FMD was lower in the PCOS groups than control. Obestatin was positively correlated with cardiovascular risk factor (FMD), whereas Copeptin was negatively correlated with FMD Conclusion(s): Obestatin and Copeptin may provide useful information regarding future cardiovascular risk in PCOS patients as Obestatin was negatively correlated and Copeptin was positively correlated with cardiovascular risk factor (FMD). Keywords: Cardiovascular diseases, Copeptin, Insulin resistance, Obesity, Obestatin, Polycystic ovary