Abstract
BackgroundDepression is a common comorbidity among patients with Chronic Obstructive Pulmonary Disease (COPD) and has a significant impact on the course of the disease. The aim of this study is to determine association between COPD Assessment Test (CAT) and major depression among clinically stable out-patient COPD subjects with mild hypoxemia.MethodsCase–control study. Cases were 30 patients with major depression and controls were 30 patients without depression. Major depression was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders criteria by a psychiatric evaluation. All possible predictive variables were included in a multivariate logistic regression model to assess the association between major depression and each independent variable, while controlling for the sleep parameters.ResultsCAT score >20 was associated with major depression (OR 7.88; 95% CI 1.96 - 31.7; p = 0.004).ConclusionCAT score >20 was associated with major depression, suggesting CAT as a predictor variable of major depression among COPD patients with mild hypoxemia, and indicating that an additional specific evaluation for the presence of major depression should be done.
Highlights
Depression is a common comorbidity among patients with Chronic Obstructive Pulmonary Disease (COPD) and has a significant impact on the course of the disease
Several studies addressed this issue, [11,12,13,14,15,16] and found that COPD Assessment Test (CAT) scores are significantly associated with the presence of symptoms of depression measured by Hospital Anxiety and Depression Scale (HADS) or patient health questionnaire-9 (PHQ-9) scores, but to the best of our knowledge, there is no data evaluating the association between CAT scores and major depression diagnosed by a psychiatric evaluation
The aim of the present study is to determine the association between CAT score and major depression diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria by a psychiatric evaluation among clinically stable out-patient COPD subjects with mild hypoxemia
Summary
Depression is a common comorbidity among patients with Chronic Obstructive Pulmonary Disease (COPD) and has a significant impact on the course of the disease. It was hypothesized that COPD patients with symptoms of depression could report higher CAT scores (because of worse health status) compared to those without depression, as CAT scores are strongly positively correlated with St George’s Respiratory Questionnaire (SGRQ) scores [11] Several studies addressed this issue, [11,12,13,14,15,16] and found that CAT scores are significantly associated with the presence of symptoms of depression measured by Hospital Anxiety and Depression Scale (HADS) or patient health questionnaire-9 (PHQ-9) scores, but to the best of our knowledge, there is no data evaluating the association between CAT scores and major depression diagnosed by a psychiatric evaluation. The aim of the present study is to determine the association between CAT score and major depression diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders (DSM IV) criteria by a psychiatric evaluation among clinically stable out-patient COPD subjects with mild hypoxemia
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