Abstract
The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-inflammatory and healing agent. However, there are no investigations on the possible anti-inflammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-inflammatory and neuroprotective effects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system.
Highlights
Inflammation is involved in several diseases of both neural and nonneural tissues [1]
The results suggest that copaiba oil-resin (COR) treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system
We investigated the effects of COR treatment on tissue preservation, neutrophil infiltration, and microglia/macrophage activation following an NMDA-induced excitotoxic damage to the motor cortex of adult rats
Summary
Inflammation is involved in several diseases of both neural and nonneural tissues [1]. Following acute neural disorders, including stroke and brain and spinal cord trauma, an intense inflammatory reaction is elicited [2] In these diseases, recruitment of neutrophils and lymphocytes occurs in an early phase [3, 4] followed by an intense microglia/macrophage activation in latter stages [4,5,6]. Experimental blockage of neutrophil recruitment with an anti-P-selectin monoclonal antibody [14] or inhibition of microglial activation with the semisynthetic tetracycline minocycline [10] induces neuroprotection following acute neural disorders. These anti-inflammatory therapies are a promising approach for central nervous system (CNS) human diseases [15, 16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
