Abstract
Two mononuclear coordination complexes of N-(2-aminophenyl)-2-(5-methyl-1H-pyrazol-3-yl)acetamide (L1), namely [Cd(L1)2Cl2] (C1) and [Cu(L1)2(C2H5OH)2](NO3)2 (C2) and one mononuclear complex [Fe(L2)2(H2O)2](NO3)2·2H2O (C3), obtained after in situ oxidation of L1, have been synthesized and characterized spectroscopically. As revealed by single-crystal X-ray diffraction, each coordination sphere made of two heterocycles is completed either by two chloride anions (in C1), two ethanol molecules (in C2) or two water molecules (in C3). The crystal packing analysis of C1, C2 and C3, revealed 1D and 2D supramolecular architectures, respectively, via various hydrogen bonding interactions, which are discussed in detail. Furthermore, evaluation in vitro of the ligands and their metal complexes for their antibacterial activity against Escherichia coli (ATCC 4157), Pseudomonas aeruginosa (ATCC 27853), Staphylococcus aureus (ATCC 25923) and Streptococcus fasciens (ATCC 29212) strains of bacteria, revealed outstanding results compared to chloramphenicol, a well-known antibiotic, with a normalized minimum inhibitory concentration as low as 5 μg mL−1.
Highlights
In order to search for new ligand candidates for assemblies of metal complexes, we considered the case of pyrazole acetamide ligands with O and N donor atoms
We found that two strong hydrogen bonding N–H/O and N–H/Cl are presented in the crystal structure of C1 which corroborated well with their 2D ngerprints; meaning the contributions of the interatomic contacts to the HF such as Cl/H/H/Cl (16.1%) and O/H/H/O (7.3%)
Crystal structure and Hirshfeld Surface analysis have shown that the crystal lattices of all the complexes are in uenced for the presence of several intermolecular interactions, including hydrogen bonds
Summary
Nitrogen-based ligands are attracting growing attention due to their interesting properties in structural and inorganic chemistry. Pyrazole derivatives are biologically active heterocyclic compounds. This substance class has been the topic of numerous pharmaceutical studies being used for their medicinal properties such as anti-in ammatory, antidiabetic, antiviral, analgesic, antitumor, catecholase, and antimicrobial properties.. Nitrogen-based ligands are attracting growing attention due to their interesting properties in structural and inorganic chemistry.. Pyrazole derivatives are biologically active heterocyclic compounds.. Pyrazole derivatives are biologically active heterocyclic compounds.6–8 This substance class has been the topic of numerous pharmaceutical studies being used for their medicinal properties such as anti-in ammatory, antidiabetic, antiviral, analgesic, antitumor, catecholase, and antimicrobial properties.. In order to search for new ligand candidates for assemblies of metal complexes, we considered the case of pyrazole acetamide ligands with O and N donor atoms.. In order to search for new ligand candidates for assemblies of metal complexes, we considered the case of pyrazole acetamide ligands with O and N donor atoms.38–40 These molecules are interesting as ligands for the construction of polynuclear complexes as models for bioinorganic systems.. 27853), Staphylococcus aureus (ATCC 25923) and Streptococcus fasciens (ATCC 29212) strains of bacteria
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