Coordinate regulation of neutrophil secondary granule protein gene expression.

Abstract

Evidence from study of both normal and leukemic cells suggests that a crucial step in neutrophil maturation occurs in the transition from the promyelocyte to the myelocyte stage. The transition from the promyelocyte to the myelocyte in normal marrow cells is accompanied both by the loss of proliferative capacity associated with terminal maturation [1], and by the loss of the capacity for alternative maturation [2]. Normal promyelocytes respond to stimuli of both granulocyte and monocyte differentiation, but myelocytes are restricted to terminal granulocyte maturation [2]. In this regard, it is striking that acute myeloid leukemias invariably involve proliferation of cells arrested in development at or before the promyelocyte stage. Consequently, an understanding of the transition from the promyelocyte to the myelocyte stage should provide crucial insights into both the control mechanisms governing normal hematopoietic cell differentiation and the ways in which disruption of the control mechanisms can contribute to leukemic transformation.KeywordsHL60 CellMature NeutrophilSecondary GranuleNeutrophil DifferentiationNeutrophil MaturationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.