Abstract
The amount of manganese superoxide dismutase (MnSOD) and the activity of copperzinc superoxide dismutase (CuZnSOD) have been studied in five karyotypically normal human fibroblast strains, using nuclear magnetic resonance (NMR) and polarographic methods. A significant correlation between the two enzyme activities, and a linear increase of MnSOD with the increase of CuZnSOD have been demonstrated. Both enzymes are present in nuclei, mitochondria, lysosome-microsome fraction and cytosol. These findings suggest that the two enzymes dismutate the O 2 − cooperatively and that a common genetic control maintains the relative amounts of the two enzymes constant.
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