Abstract
Background: The Hippo pathway with its two downstream effectors, the transcriptional co-activators YAP (yes-associated protein) and TAZ (WW Domain Containing Transcription Regulator 1), is a central regulator of organ size. Inactivation of this pathway or overexpression of YAP has been demonstrated to induce hepatomegaly and liver cancer in mice. TAZ has been implicated in the regulation of epithelial-mesenchymal transition (EMT) and invasiveness of breast cancer cells. However, comparative analyses on the expression and cooperative function of YAP and TAZ under physiological conditions (e.g. liver regeneration) and during hepatocarcinogenesis are missing.
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