Cooperative catalysis of carbenes and Lewis acids for the highly enantioselective synthesis of dihydroquinolones via in situ generation of aza-ortho-quinone methide and enolate intermediates

Abstract

An efficient protocol for the highly enantioselective synthesis of dihydroquinolones was developed via NHC-catalyzed [4 + 2] annulation between in situ generated aza-ortho-quinone methide and enolate intermediates.