Cooperative catalysis: enantioselective propargylic alkylation of propargylic alcohols with enecarbamates using ruthenium/phosphoramide hybrid catalysts.

Abstract

The diastereo- and enantioselective propargylic alkylation of propargylic alcohols with E-enecarbamates in the presence of a catalytic amount of thiolate-bridged diruthenium complexes bearing an optically active phosphoramide moiety gives the corresponding propargylic alkylated products (up to 97 % ee).