Abstract
Background Hemolytic Anemia is very common during pregnancy especially in malaria endemic areas. It often associated with Tropical Splenomegaly Syndrome (now commonly known as Hyper-Reactive Malarial Splenomegay), which is an autoimmune phenomenon that follows episodes of malaria in the past. Very few cases of Coombs Negative Hemolytic Anemia have been reported in literature. This condition has not yet been described in Sub-Saharan Africa; hence we are presenting the first such case.
Highlights
Hemolytic Anemia is very common during pregnancy especially in malaria endemic areas [1]
Very few cases of Coombs Negative Hemolytic Anemia have been reported in literature [3,4]
Hemolytic anemia can be prevalent during pregnancy, and the mechanism is thought to be related to an autoimmune response resulting into a phenomenon called the Tropical Splenemegaly Syndrome (TSS), currently referred to as Hyperactive Malarial Splenomegaly [1,2,9]
Summary
Hemolytic Anemia is very common during pregnancy especially in malaria endemic areas [1]. A 34-year-old grand multiparous Tanzanian woman, at 22 weeks gestation, was referred from a nearby health facility due to difficulty in breathing, awareness of heart beats, and easy fatigability for over a period of one month She denied a history of bleeding, or ruptures of membranes, and has perceived fetal movements normally. Her cardiovascular assessment showed a pulse rate of 78 beats per minute, a blood pressure of 110/80 mmHg, and a functional ejection systolic murmur at the apex. Scan at GA of 33 weeks showed an estimated fetal weight of 2.1 kg with an amniotic fluid index of 13 cm She was started on daily Blood transfusions for several weeks with no improvement of her hematocrit.
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