Abstract
Rats with hippocampal lesions, rats with neocortical lesions, and others with sham operations were tested for electroshock seizure threshold (EST) and for threshold to maximal electroshock seizure (MES) as measured by hind limb extension. The EST was significantly lower in animals with hippocampal and neocortical lesions than in those with sham operations. The rats with hippocampal lesions had not only a lower threshold to hind limb extension than either of the other two groups, but also a longer duration of clonus and longer duration of the total MES. These results suggest that neocortex and hippocampus both play inhibitory roles with regard to neural mechanisms underlying the EST, while only the hippocampus has an inhibitory influence upon neural mechanisms underlying threshold to hind limb extension and duration of clonus in the MES.
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