Convolutional neural network-based automatic liver delineation on contrast-enhanced and non-contrast-enhanced CT images for radiotherapy planning.

Abstract

This study evaluated a convolutional neural network (CNN) for automatically delineating the liver on contrast-enhanced or non-contrast-enhanced CT, making comparisons with a commercial automated technique (MIM Maestro®). Intensity-modulated radiation therapy requires careful labor-intensive planning involving delineation of the target and organs on CT or MR images to ensure delivery of the effective dose to the target while avoiding organs at risk. Contrast-enhanced planning CT images from 101 pancreatic cancer cases and accompanying mask images showing manually-delineated liver contours were used to train the CNN to segment the liver. The trained CNN then performed liver segmentation on a further 20 contrast-enhanced and 15 non-contrastenhanced CT image sets, producing three-dimensional mask images of the liver. For both contrast-enhanced and non-contrast-enhanced images, the mean Dice similarity coefficients between CNN segmentations and ground-truth manual segmentations were significantly higher than those between ground-truth and MIM Maestro software (p < 0.001). Although mean CT values of the liver were higher on contrast-enhanced than on non-contrast-enhanced CT, there were no significant differences in the Hausdorff distances of the CNN segmentations, indicating that the CNN could successfully segment the liver on both image types, despite being trained only on contrast-enhanced images. Our results suggest that a CNN can perform highly accurate automated delineation of the liver on CT images, irrespective of whether the CT images are contrast-enhanced or not.