Conversion to belatacept maintenance immunosuppression in HIV-positive kidney transplant recipients.

Abstract

There are only scattered case reports documenting belatacept use in HIV+kidney transplant recipients. We performed a retrospective review to describe short-term outcomes following conversion to belatacept in a cohort of HIV+patients. Patients were included if they were converted to belatacept between May 2015 and May 2019, had an HIV- donor, and received ≥4 doses of belatacept. All patients were treated with non-depleting induction and triple maintenance immunosuppression. Allograft and HIV-related outcomes were collected from the date of belatacept infusion until May 2020. Ten HIV+kidney transplant recipients were identified, who were converted to belatacept a median of 364days post-transplant. At last follow-up (median 3.3years), 8 patients remained on belatacept therapy, and all patients were alive with functioning allografts. Mean estimated glomerular filtration rates (eGFR) improved from 31.6mL/min at baseline to 42.8mL/min at 1year (P=.03). Two patients developed acute rejection, with one necessitating conversion back to tacrolimus. All patients maintained undetectable HIV-1 viral loads at last follow-up. One patient each developed pneumocystis pneumonia and Kaposi sarcoma following conversion, which were responsive to standard medical therapy. In our cohort of stable HIV+kidney transplant recipients, conversion to belatacept was associated with excellent early patient and allograft survival and improved eGFR at 1year.