Abstract
Rat polymorphonuclear leukocytes metabolize leukotriene B 4 (LTB 4) by at least two major pathways. LTB 4 is converted by a reductase in these cells to a dihydro metabolite in which one of the three conjugated double bonds has been reduced to give a conjugated diene with a UV absorption maximum at 230 nm. DihydroLTB 4 appears to be a key intermediate in the metabolism of LTB 4 by rat polymorphonuclear leukocytes, since a number of other metabolites, exhibiting UV absorbance at 235 nm, but not at 280 nm, have been detected by high pressure liquid chromatography. In addition, these cells contain a 19-hydroxylase, which converts LTB 4 to 19-hydroxyLTB 4, which has a typical leukotriene UV spectrum, exhibiting absorption maxima at 261, 270, and 282 nm.
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