Abstract
The incorporation of radioactivity from orally administered tritium-labeled phytol into phytanic acid of plasma triglycerides, phospholipids, and cholesterol esters was studied in a patient with heredopathia atactica polyneuritiformis (Refsum's disease). Radioactivity was very rapidly incorporated into triglyceride fatty acids. There was a much slower uptake of the label into phospholipid fatty acids. Despite their low content of phytanic acid, radioactivity was as rapidly incorporated into cholesterol ester fatty acids as into triglyceride fatty acids. Specific radioactivities of phytanic acid showed a similar time course. From this incorporation pattern it is concluded that plasma cholesterol esters and triglycerides act as the main vehicles for phytanic acid newly synthesized from exogenous phytol. Reduction of chlorophyll intake might be tried for lowering the phytanic acid content in the plasma of patients with heredopathia atactica polyneuritiformis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
