Abstract
AbstractThe cover picture shows the key steps of a convergent and versatile synthesis of Syringolin A (SylA) and other syrbactins. SylA is a small‐molecule virulence factor produced by some plant pathogenic Pseudomonas syringae pv. syringae strains during infection. It leads to irreversible inhibition of the plant's 20S proteasome (lower right corner depicts the binding mode of SylA to one of the active‐site centres of the proteasome), resulting in the so‐called brown‐spot disease. The synthetic preparation of SylA and its analogues opens up further possibilities for biological investigation into the mode of action of SylA in plant–pathogen interactions. Details are discussed in the article by M. Kaiser et al. on p. 3991 ff.
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