Convergent inputs from articular, cutaneous and muscle receptors onto ascending tract cells in the cat spinal cord

Abstract

Responses were recorded from 160 ascending tract cells in segments L4 to L6 of the spinal cord in chloralose anaesthetized, spinalized cats. The tract cells were identified by antidromic activation following stimulation of pathways in the lateral and ventral funiculi at the level of the spinal cord transection at the thoracolumbar junction. Axonal conduction velocities ranged from 9 to 114 m/s. A sample of 152 of the neurones examined could be subdivided according to the distribution of their receptive fields into 49 cells activated just from receptors located in skin ("s" cells), 17 neurones excited by receptors in deep tissues ("d" cells), 15 units with a convergent input from receptors in skin and deep tissues ("sd" cells), and 25 neurones with a convergent input from the knee joint and either skin ("sj" cells), deep tissues ("dj" cells) or both ("sdj" cells). No receptive fields could be demonstrated for the remaining 46 neurones. "S" and "sj" cells were found almost exclusively in the dorsal horn, whereas many "d", "sd", "sdj" and "dj" units were in the ventral horn. Almost all of the cells that lacked receptive fields were in the ventral horn or intermediate grey. Ninety-one of 158 cells (56%) demonstrated no background activity. Of these, 43 cells (27%) lacked receptive fields. Many of the silent neurones were in the ventral horn, but some were in the dorsal horn. Of 25 cells having knee joint input, 18 (72%) had background activity. All of the neurones that had a receptive field in the knee joint also had a convergent input from receptors in other tissues. In 3 cases, there was a receptive field in the skin over the foot ("sj" cells). For 16 cells, receptive fields included not only the knee joint but also skin and deep tissue ("sdj" cells). Usually, the cutaneous receptive field was near the knee joint, but sometimes it was remote, such as on the foot. The deep receptive fields were chiefly in the muscles of the thigh and/or leg. For 6 "dj" cells, the receptive fields included not only the knee joint but also deep fields like those of "sdj" cells. Cutaneous receptive fields were classified as "low threshold" (cells excited best by innocuous intensities of mechanical stimulation), "wide dynamic range" (cells activated by weak mechanical stimuli, but the best responses were to noxious stimuli) or high threshold (innocuous stimuli had little effect, but noxious mechanical stimuli produced a vigorous discharge).(ABSTRACT TRUNCATED AT 400 WORDS)