Conventional MRI as a diagnostic and prognostic tool in spinal cord injury: a systemic review of its application to date and an overview on emerging MRI methods

Abstract

The diagnosis and prognosis of traumatic spinal cord injury has historically relied on clinical examination whereby those presenting with severe injuries were deemed unlikely to recover and those presenting with mild injuries were deemed more likely to recover. With the widespread use of MRI to visualize traumatic injury to the spinal cord, a spectrum of previously unseen characteristics ranging from mild T2-weighted signal intensity to complete spinal cord transection is now available to aid in both the diagnosis and prognosis. In this systematic review, the authors outline how clinical examination (using the American Spinal Injury Association standards) and MRI characteristics can be used to classify and characterize acute traumatic cervical spinal cord injury. The reader will gain an appreciation for the different magnetic resonance signal characteristics that can be used to predict a favorable or unfavorable prognosis following traumatic spinal cord injury. The accuracy of this information, in terms of sensitivity and specificity, is presented. Using likelihood ratios, the authors work through specific examples. The use of MRI in the evaluation of the human spinal cord has aided our understanding of the condition significantly. However, there are still several challenges that need to be met, in particular the use of MRI to detect functional abnormalities as well as structural ones. In the coming years, our ability to define damaged circuits in the spinal cord will mean that it will be possible to link structure to function in an objective non-invasive way, which will have implications for the understanding and potential treatment of spinal cord injury.