Conventional margins not sufficient for post-prostatectomy prostate bed coverage: An analysis of 477 cone-beam computed tomography scans

Abstract

PurposeTo study prostate bed deformation, and compare coverage by 5mm and 10mm posterior expansion PTV margins. MethodFifty patients who completed post-prostatectomy radiotherapy had two expansion margins applied to the planning CT CTV: PTV10 (10mm isometrically) and PTV5 (5mm posteriorly, 10mm all other directions). The CTV was then contoured on 477 pre-treatment CBCTs, and PTV5 and PTV10 coverage of each CBCT-CTVs was assessed. The maximum distance from the planning CT CTV to the combined CTV of all CBCTs including the planning CT CTV was measured for the superior part of the prostate bed, and the inferior part of the prostate bed, for every patient. ResultsThe mean difference between largest and smallest CBCT-CTVs per patient was 18.7cm3 (range 6.3–34.2cm3). Out of 477 CBCTs, there were 43 anterior geometric geographical misses for either PTV with a mean volume of 2.25cm3 (range 0.01–18.88cm3). For PTV10, there were 26 posterior geometric geographical misses with a mean volume of 1.37cm3 (0.01–11.02cm3). For PTV5, there were 46 posterior geometric geographical misses with a mean volume of 3.22cm3 (0.01–19.82cm3). The maximum edge-to-edge distance for the superior prostate bed was anterior 19mm, posterior 16mm, left and right 7mm. The maximum edge-to-edge distance for the inferior prostate bed was anterior 4mm, posterior 12mm, left and right 7mm. ConclusionThis study supports differential margins for the superior and inferior portions of the prostate bed. Because of the large deformation of CTV volume seen, adaptive radiotherapy solutions should be investigated further.