Abstract
Michael-type addition reactions of Ni(II)-complex of a dehydroalanine Schiff base and ethyl bromodifluoroacetate in the presence of copper for the synthesis of racemic 4,4,-difluoroglutamic acid derivatives were developed. These reactions proceeded smoothly and gave the desired product in 80% yield. Furthermore, this procedure is of low cost-structure, operationally convenient, and scalable.
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