Abstract
A simple, efficient and eco-friendly "one-pot" method for the convenient synthesis of imidazo-fused heterocycles has been developed. The reaction was catalyzed by CeCl 3 ·7H 2 O in ethanol under 60 ℃ via Groebke-Blackburn-Bienayme (GBB) reaction of aldehydes, aminoazines and isocyanides. This method has many advantages of a wide range of substrates, short reaction time and easy purification. In addition, we conducted a comparative study of LaCl 3 ·7H 2 O with CeCl 3 ·7H 2 O on their catalytic effect under the same reaction conditions, and found that CeCl 3 ·7H 2 O was comparable to LaCl 3 ·7H 2 O as catalyst in GBB reaction.
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