Abstract
AbstractThe domino [2+2+2] cycloaddition reaction of α,β‐unsaturated N‐arylaldimines, dialkyl acetylenedicarboxylates, and arylidenemalononitriles in dry acetonitrile at room temperature afforded polysubstituted 6‐styryl‐1,4,5,6‐tetrahydropyridines in good yields with various cis/trans‐isomer ratios. The similar three‐component reaction that contains ethyl arylidenecyanoacetates or arylidenepivaloylacetonitriles also resulted in polysubstituted 6‐styryl‐1,4,5,6‐tetrahydropyridines, which can be separated into pure cis‐ and trans‐isomers. The stereochemistry of the obtained polysubstituted 1,4,5,6‐tetrahydropyridines is clearly elucidated on the basis of 1H NMR spectroscopy and single‐crystal structures.
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