Abstract
The ability of ethylenediaminetetraacetic acid (EDTA) and its derivatives to form stable complexes with a variety of metal ions allows for their use as probes in various areas in chemistry, biology, and medicine. Derivatives of EDTA-Fe, for example, are effective cleavage reagents used to investigate biomolecular structure and function. Protein and nucleic acid cleavage experiments have been used to probe biomolecule tertiary structure and drug binding sites, as well as to identify folding intermediates and to investigate interactions with other macromolecues.l Complexation of radioactive metals, alternatively, with these EDTA reagents has found extensive utility in medicine.2 Accordingly, there have been several syntheses of reagents capable of delivering and attaching these chelates to various macromolecules.3 Here we report the facile synthesis of three novel reagents useful for linking an EDTA chelate covalently to a protein or nucleic acid-borne thiol. Pyndine disulfide
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