Convenient removal of N- tert-butyl from amides with scandium triflate

Abstract

Scandium triflate has been used as a convenient and efficient catalyst for removal of N- tert-butyl from amide groups. A variety of N- tert-butyl aryl and alkyl amides under these conditions gave the corresponding primary amide in high yields. With the use of microwave heating the deprotection reaction could be completed within 1 h.