Abstract
A facile one-pot synthetic method of building aryloxyalkyl esters was developed using various types of phenolic esters with halogenated alcohols. The ready availability of both starting materials, coupled with the required simple experimental technique, enables the current synthetic method of producing aryloxyalkyl esters in a fast and efficient way. It is noteworthy that acyl transfer was demonstrated in this reaction.
Highlights
Phenols are typically protected by various groups to enhance their leaving ability in cross-coupling reactions [1,2,3]
Aryloxyalkyl ester (3ba), was serendipitously obtained through the reaction displayed in Scheme 2
We investigated the effects of reaction parameters in this new aryloxyalkyl esterification
Summary
Phenols are typically protected by various groups to enhance their leaving ability in cross-coupling reactions [1,2,3]. A type of aryl C-O electrophiles, are considered as notable functional groups or protecting groups in organic synthesis, and can be found in various bioactive natural products, agrochemicals, pharmaceuticals, and functional polymers [29,30,31]. Aryloxyalkyl ester (3ba), was serendipitously obtained through the reaction displayed in Scheme 2. Ester (3ba), was serendipitously obtained through the reaction displayed displayed in in Scheme. The efficiency of these protocols was restricted from the view of step economy for the synthesis of a variety of substituents. Disclose a convenient synthesis of aryloxyalkyl esters from phenolic esters with halogenated alcohol. Synthesis ofsynthesis aryloxyalkyl esters from phenolic esters with halogenated alcohol. Convenient of aryloxyalkyl esters from phenolic esters with halogenated alcohol.
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