Abstract
We have developed a convenient and efficient method for the synthesis of nucleoside phosphoramidate monoesters. This step-wise synthesis, consisting of an ester exchange, reaction of the 5'-OH of nucleosides with fluorenylmethyl aryl phosphite, and an Atherton-Todd reaction, gave fluorenylmethyl nucleoside 5'-phosphoramidates; final removal of the fluorenylmethyl group yielded the desired target products in good yields.
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