Abstract

We have developed convenient and general MAOS protocols for the synthesis of functionalized 1,2,4-triazines, canthines, imidazoles, quinoxalines, pyrazines, quinoxalinones, and 5-aminooxazoles. The methodology described herein makes use of readily available building blocks, facilitating the generation of structurally diverse analog libraries to support nascent medicinal chemistry programs. Other advantages over classical heating conditions include shortened reaction times, increased yields, and the suppression of side product formation.

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