Abstract
In The Lancet Respiratory Medicine, Andrea Alemany and colleagues1 report the results of CONV-ERT, a multicentre, double-blind, randomised controlled trial (RCT), administering locally sourced, high-titre COVID-19 convalescent plasma or saline to 376 outpatients in Spain. We commend the investigators for designing and implementing a rigorous outpatient trial during the difficulties of the pandemic. The study was among the few RCTs designed to deliver COVID-19 convalescent plasma to patients with early disease who were mostly seronegative, for whom antiviral therapies are most likely to succeed.
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