Abstract

Stirring promotes formation of the metastable α glycine polymorph, whereas stable γ glycine forms under quiescent conditions.

Highlights

  • Glycine is used to treat a variety of health issues, including anxiety, schizophrenia and insomnia.[12]

  • Our results show that stirring promotes formation of the metastable α polymorph which could be due to primary nucleation of a metastable polymorph, or due to secondary nucleation

  • Crystallisation resulted in preferential formation of γ glycine

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Summary

Introduction

Glycine is used to treat a variety of health issues, including anxiety, schizophrenia and insomnia.[12]. The least stable polymorph β, has been observed to be rapidly replaced (within a few minutes) by α in agitated aqueous solutions.[11,23] α is a metastable polymorph and under agitation in aqueous solutions it is very slowly replaced by the stable γ polymorph (reported to start after 35 hours[24]). Mechanisms of these replacements are not fully

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Conclusion

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