Abstract
Odontogenic tumours are lesions that occur solely within the oral cavity and are so named because of their origin from the odontogenic (i.e. tooth-forming) apparatus. Odontogenic tumours comprise a variety of lesions ranging from non-neoplastic tissue proliferations to benign or malignant neoplasms. However, controversies exist regarding the pathogenesis, categorisation and clinical and histological variations of these tumours. The recent 2017 World Health Organization classification of odontogenic tumours included new entities such as primordial odontogenic tumours, sclerosing odontogenic carcinomas and odontogenic carcinosarcomas, while eliminating several previously included entities like keratocystic odontogenic tumours and calcifying cystic odonogenic tumours. The aim of the present review article was to discuss controversies and recent concepts regarding odontogenic tumours so as to increase understanding of these lesions.
Highlights
Controversies in Odontogenic Tumours ReviewAbstract: Odontogenic tumours are lesions that occur solely within the oral cavity and are so named because of their origin from the odontogenic (i.e. tooth-forming) apparatus
Odontogenic tumours are lesions that occur solely within the oral cavity and are so named because of their origin from the odontogenic apparatus
The present review aimed to provide insight into different controversies and recent developments in this field, with regards to the recent 2017 World Health Organization (WHO) classification of odontogenic tumours.[2]
Summary
Abstract: Odontogenic tumours are lesions that occur solely within the oral cavity and are so named because of their origin from the odontogenic (i.e. tooth-forming) apparatus. Both intraosseous and extraosseous, can involve the maxillary and mandibular regions of the jaw; of these, odontogenic tumours are unique to the oral cavity and do not occur elsewhere in the body These tumours originate from tissues involved in odontogenesis (i.e. tooth development) and include a wide variety of lesions ranging from hamartomas to non-neoplastic tissue proliferations and both benign and malignant neoplasms.[1,2] Due to this wide range of biological behaviour, there is currently much debate regarding the pathogenesis, classification and clinical and histological variations of odontogenic tumours.[1] The present review aimed to provide insight into different controversies and recent developments in this field, with regards to the recent 2017 World Health Organization (WHO) classification of odontogenic tumours.[2] Awareness of such controversies may aid in a better understanding of these pathological entities as well as enhancing their diagnosis and management. Due to subsequent advancements in diagnostic immunohistochemistry, molecular biology and genetics, as well as clinical and epidemiological follow-up, modifications were made to the previous 2005 WHO classification in 2017 wherein some lesions were newly added, removed or reclassified; in addition, attempts were made to simplify the classification system, discarding subtypes or suffixes that lacked clinical relevance.[2,4,5] Table 2 provides a summary of the entities which were either newly included or excluded from the WHO 2017 classification.[2,4]
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