Abstract
Background MYH-Associated Polyposis (MAP) is an autosomal recessive condition caused by bi-allelic mutations in MYH. Individuals with MAP tend to develop numerous polyps in their colon and rectum and have an increased risk of developing colorectal cancer. Recommendations for MAP treatment vary in the literature ranging from frequent surveillance colonoscopy to prophylactic surgery depending on polyp burden. The aim of this study was to report the management and outcome of a single institution series of patients with MAP. Methods Patients with biallelic mutations in MYH were accrued over 23 years from a query of a comprehensive polyposis database using Cologene© software. Demographics, family history, upper and lower endoscopy frequency, polyp burden, and cancer data, and treatment were recorded.
Highlights
MYH-Associated Polyposis (MAP) is an autosomal recessive condition caused by bi-allelic mutations in MYH
Recommendations for MAP treatment vary in the literature ranging from frequent surveillance colonoscopy to prophylactic surgery depending on polyp burden
6/20 yes Methods Patients with biallelic mutations in MYH were accrued over 23 years from a query of a comprehensive polyposis database using Cologene© software
Summary
MYH-Associated Polyposis (MAP) is an autosomal recessive condition caused by bi-allelic mutations in MYH. Individuals with MAP tend to develop numerous polyps in their colon and rectum and have an increased risk of developing colorectal cancer. Recommendations for MAP treatment vary in the literature ranging from frequent surveillance colonoscopy to prophylactic surgery depending on polyp burden. The aim of this study was to report the management and outcome of a single institution series of patients with MAP. Synchronous (N=4) Solitary (N=10) Gender M – 50% F – 50% M – 60% F – 40% Age Mean 51 Family History 3/4 yes
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