Controlling Surface Wettability for Automated In Situ Array Synthesis and Direct Bioscreening (Adv. Mater. 36/2021)

Abstract

Coatings In article number 2102349, Yixin Zhang and co-workers report an amphiphilic coating for glass surfaces, on which small droplets of polar aprotic organic solvents can be deposited with an enhanced contact angle (small feature size) and inhibited motion (strong binding), permitting fully automated multiple rounds of combinatorial synthesis of small-molecule compounds and peptides. The amphiphilic coating can be switched to hydrophilic network for protein- and cell-based screening.