Abstract
BackgroundIt is well established that the controlling nutritional status (CONUT) score was correlated with long-term outcomes in gastric cancer (GC), but the significance of CONUT for postoperative short-term outcomes remains unclear. The study aimed to characterize the relationship between CONUT and short-term complications following gastrectomy of GC.MethodsWe collected data on 1479 consecutive GC patients at Nanjing Drum Tower Hospital between January 2016 and December 2018. Univariate and multivariate analyses of predictive factors for postoperative complications were performed. The cutoff value of the CONUT score was determined by Youden index.ResultsAmong all of the patients, 431 (29.3%) patients encountered postoperative complications. Multivariate analyses identified CONUT was an independent predictor for postoperative short-term complications (OR 1.156; 95% CI 1.077–1.240; P < 0.001). Subgroup analysis elucidated that CONUT was related to postoperative complications both in early gastric cancer and advanced gastric cancer. We further explored that patients with high CONUT score had prolonged hospital stay (12.3 ± 6.0 vs 11.1 ± 4.6, P < 0.001) and more total hospital charges (7.6 ± 2.4 vs 7.1 ± 1.6, P < 0.001).ConclusionsThe present study demonstrated that the preoperative CONUT was an independent predictor for short-term complications following gastrectomy of GC.
Highlights
It is well established that the controlling nutritional status (CONUT) score was correlated with longterm outcomes in gastric cancer (GC), but the significance of CONUT for postoperative short-term outcomes remains unclear
We further explored the relationship between postoperative short-term complications and CONUT score in different pathological stages
In this study, we evaluated the predictive ability of various nutritional and inflammatory parameters for short-term complications following gastrectomy of GC, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), Prognostic Nutritional Index (PNI), and CONUT
Summary
It is well established that the controlling nutritional status (CONUT) score was correlated with longterm outcomes in gastric cancer (GC), but the significance of CONUT for postoperative short-term outcomes remains unclear. Gastric cancer (GC) is one of the most common digestive tract cancers worldwide [1] To this day, radical gastrectomy remains the main option for resectable GC. Despite significant advance has been seen in surgical techniques in recent years, the incidence of complications after radical gastrectomy remains at 15%-25% [2, 3]. It is Malnutrition is common in GC patients because of a decrease in food intake and energy expenditure. Sun et al BMC Gastroenterol (2021) 21:107 more reliable combined scoring systems were developed to accurately predict patient prognoses, such as neutrophil to lymphocyte ratio (NLR), Prognostic Nutritional Index (PNI), and platelet to lymphocyte ratio (PLR) [8, 11, 12]
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