Controlled study of serum cytokines and high-sensitive C-reactive protein in the post-stroke depression and depression patients

Abstract

Objective To compare the serum cytokines and high-sensitive C-reactive protein (hs-CRP)in the post-stroke depression(PSD) and depression patients, and further study of the pathogenesis PSD and depression. Methods The levels of serum IL-1β, IL-6 and TNF-α in the PSD group(n=30), the depression group(n=30), the post-stroke non-depression group(n=30)and normal control group(n=30)were measured with enzymatic-linked immunosorbent assay(ELISA) , and the levels of serum hs-CRP were measured by scatter rate nephelometryat for these four groups. Results The levels of serum IL-1β, IL-6, TNF-α and hs-CRP in the PSD group, the depression group, the the post-stroke non-depression group and the normal control group were respectively((137.23±8.12)pg/ml, (34.12±3.12) pg/ml, (64.62±6.11)pg/ml, (15.36±6.25)mg/L); ((133.21±7.56)pg/ml, (33.56±2.65) pg/ml, (62.95±5.66)pg/ml, (4.02±1.21)mg/L); ((43.25±6.23)pg/ml, (16.12±2.60) pg/ml, (32.23±7.12)pg/ml, (14.88±7.23)mg/L); ((42.12±5.78)pg/ml, (15.32±3.23) pg/ml, (31.55±6.70)pg/ml, (3.68±1.11)mg/L). The levels of serum IL-1β, IL-6 and TNF-α in the PSD group and the depression group increased significantly than those in the the post-stroke non-depression group and the normal control group(P post-stroke non-depression group > depression group > normal control group(P<0.05). Conclusion The PSD and depression may have the same immune mechanism. Key words: Post-stroke depression; Depression; Cytokines; hs-CRP