Abstract
HypothesisStimuli-responsive polymers, with properties changing upon different environmental factor variations such as pH, light, mechanical stress or temperature, and polymeric nanoparticles have found many important applications in fields such as drug delivery, biosensing and environmental research. ExperimentsIn this work, thermoresponsive nanoparticles that are able to react by Diels-Alder reaction (a diene-dienophile cycloaddition) were studied. Thermoresponsive polymers were synthesized from a biocompatible polymer (poly(lactic-co-glycolic) acid, PLGA) and diene (furan) or dienophile (maleimide) derivatives. Emulsification-evaporation method was then used as a fast and reproducible method to obtain highly monodispersed polymeric nanosuspensions able to react by Diels-Alder (DA) reaction. FindingsThe nanoparticles’ size decreased down to 25 nm by increasing the emulsification’s time. The possible direct and retro-Diels-Alder (rDA) reactions between furan- and maleimide-functionalized nanoparticles were studied by dynamic light scattering and electron microscopy. For the first time, the reactivity of the interfacial DA and rDA reactions between functionalized-nanoparticles was studied, leading to the determination of the activation energy, the enthalpy of activation and the entropy of activation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
