Abstract
The advent of new drug therapies has resulted in a need for drug delivery that can deal with increased drug concentration and viscosities. Needle-free liquid jet injection has shown great potential as a platform for administering some of these revolutionary therapies. This investigation explores the detonative combustion phenomenon in gases as a simple and efficient means of powering needle-free liquid jet injection systems. A preliminary, large-scale prototype injector was designed and developed. In contrast with the widely used air-powered and electrical driven needle-free injectors, the proposed detonation-driven mechanism provides equivalent liquid jet evolution and performance but can efficiently provide a controllable power source an order magnitude higher in strength by varying combustible mixtures and initial conditions. The simplicity and power output associated with this concept aid in improving current needle-free liquid injector design, especially for delivery of high volume, high viscosity drugs, including monoclonal antibodies, which target precise locations in skin tissue.
Highlights
Drug delivery without the use of hypodermic needles has been a long-term objective within the medical field [1]
This study highlights the use of the detonative combustion phenomenon as a novel, alternative energy sourcehighlights to powerthe a conventional mechanical piston-type needle-freeasliquid jet alternative injector
Can generate forces much largerthis than those obtained by typicalevidence air-powered spring-loaded injection sufficient power drive a needle-free injector, producing a strongdetonation liquid jet applicable for highly. This to study provides promising evidence that a gaseous wave can generate viscous drug delivery to meet the requirements of recently emerging medical treatment
Summary
Drug delivery without the use of hypodermic needles has been a long-term objective within the medical field [1]. The basic mechanism involves the use of a power source to compress a liquid and expel it through an orifice [2] This technology has been in existence since the early 20th century, and during that period the effectiveness in eliminating bio-hazardous waste and delivering a broad range of medication have made this technology ideal for mass immunization [3]. Drawbacks such as pain, bruising, splash back, hematomas, excessive penetration and cross contamination have limited the use of needleless jet injection for both mass immunization as well as individual use [4,5,6]. The technology has gained renewed interest for delivering both micro- and macromolecules and advancements in fluid dynamic research have aided in propelling this technology as an ideal platform for newly developed drug therapies, including monoclonal antibodies [7,8]
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