Abstract
Retinol is a compound used in many skin care formulations to act against skin conditions like acne, wrinkles, psoriasis, and ichthyosis. While retinol is used as an active ingredient, its efficacy is limited by an extreme sensitivity to light and temperature. Retinol can also generate toxicity at high concentrations. Microencapsulation is an alternative method to help overcome these issues. In this study, we develop a new encapsulation of retinol by solvent evaporation using a cationic polymer. We show that our particles have a narrow size distribution (350 nm), can encapsulate retinol with high efficiency, and protect it from oxidation for at least eight weeks. Finally, to demonstrate that the release of retinol from the particles can be controlled, we performed a kinetic study and showed that the particle releases the drug during 18 h.
Highlights
The past decades have seen a growing interest in applications of drug delivery systems, especially in the fields of pharmaceutics, cosmetics, and dermo-cosmetics, where drug administration, long-lasting effect, and toxicologic studies are crucial aspects
Retinol is a derivative of vitamin A, often used as an active ingredient in many skin care formulations to reduce wrinkles, acne, UV-induced aging spots, or specific skin disorder
It is important to note that retinol has a narrow therapeutic window, leading it to be ineffective at low concentrations and toxic at high concentrations [5,9]
Summary
The past decades have seen a growing interest in applications of drug delivery systems, especially in the fields of pharmaceutics, cosmetics, and dermo-cosmetics, where drug administration, long-lasting effect, and toxicologic studies are crucial aspects. AThe polymer are dissolved in a volatile organic phase, which ismethod dispersed in an aqueous phase to solvent evaporation is one of the few processes that can encapsulate hydrophilic or phase lipophilic form an oil-in-water (O/W) emulsion. Polymer are dissolved in a volatile organic phase, which is dispersed in an aqueous phase to form an Previous studies have shown the interest in cationic particles for skin or hair formulation: the oil-in-water (O/W). The organic solvent diffuses into the externaltophase and evaporates, affinity of the particles with the treated anionic surface (the skin) conducts a long-lasting effect. The permeability of Eudragit due to the employed in thehas pharmaceutical field torelease improve controlled-release drug forms [19,20].isHowever, its presence of quaternary ammonium groups in its structure
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have